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Why Miscarriage Happens

Miscarriages happen due to various factors, with some cases having identifiable causes, and others remaining uncertain. Understanding the knowable underlying causes and risk factors associated with miscarriage can help people gain insight into their own situation.

Genetic causes

  • Chromosomal anomalies in the fetus, such as the number of chromosomes, such as trisomies (three copies of a chromosome), or changes in the structure of a chromosome, such as a translocation.

  • Inherited genetic disorders that affect fetal development.

Hormonal causes

  • Imbalances in hormone levels, such as low progesterone.

  • Thyroid disorders affecting hormone regulations.

Specific medical conditions

  • Autoimmune disorders, such as antiphospholipid syndrome.

  • Uncontrolled diabetes.

Anatomical problems

  • Uterine anomalies, including septate uterus or fibroids.

  • Cervical insufficiency, where the cervix (neck of the womb) weakens or opens prematurely.

Risk factors

  • Older maternal age (if you are over 35).

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  • Behavioural risk factors, including smoking, excessive alcohol consumption, or drug use.

  • Obesity or being significantly underweight.

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Pregnancy Loss Research Group

Cork University Maternity Hospital

Wilton, Cork, Ireland

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